SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
8
Vitamin D3 shows promise for knee OA
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.
Direct focus on vitamin D effectiveness
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Read More
8
Vitamin D3 improves post-surgery pain
Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.
Highly relevant to knee surgery
We investigated the role of vitamin D3 in managing post-operative knee pain in patients undergoing unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups. One group received vitamin D3 supplements before surgery, another group received them afterward, and the last group had normal vitamin D levels from the start.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
Read More
8
Vitamin D improves knee discomfort
Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.
Direct impact on knee pain
We explored the relationship between 25-hydroxy vitamin D levels and knee osteoarthritis (KOA) by conducting a thorough analysis of eight randomized controlled trials (RCTs). This involved looking at nearly 3,100 patients and examining factors such as tibial cartilage volume, joint space width, synovial fluid volume, and patients' self-reported pain and function scores.
Our findings showed that vitamin D supplementation significantly improved certain aspects of knee health. Specifically, we observed notable reductions in pain levels and improvements in joint function, as measured by the WOMAC scale. Interestingly, while vitamin D helped with the overall discomfort and functionality of those suffering from knee issues, it did not significantly affect stiffness or some other knee-related measurements, like changes in joint space.
Given these results, it seems clear that for patients struggling with knee pain and dysfunction, vitamin D could be a valuable addition to their treatment regimen. However, it’s also worth noting that the most pronounced benefits appeared with dosages exceeding 2,000 IU daily, suggesting that dosage plays an important role in effectiveness.
Our findings showed that vitamin D supplementation significantly improved certain aspects of knee health. Specifically, we observed notable reductions in pain levels and improvements in joint function, as measured by the WOMAC scale. Interestingly, while vitamin D helped with the overall discomfort and functionality of those suffering from knee issues, it did not significantly affect stiffness or some other knee-related measurements, like changes in joint space.
Given these results, it seems clear that for patients struggling with knee pain and dysfunction, vitamin D could be a valuable addition to their treatment regimen. However, it’s also worth noting that the most pronounced benefits appeared with dosages exceeding 2,000 IU daily, suggesting that dosage plays an important role in effectiveness.
Read More
Most Useful Reviews
9.5
Immense help
I’m very pleased with the quality and effectiveness of this D3, as it has greatly aided me concerning bone and joint strength, reduced knee pain, and appears to be easily absorbed. I will continue to purchase.
Read More
8.8
Less pain
Good in composition and acceptable in dosage for an adult. I drink one piece a day and have experienced less knee pain.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
- All Researches
9
Vitamin D alleviates knee pain
Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression.
Strong relevance to knee OA
We focused on the effects of vitamin D (VITD) in reducing knee pain linked to osteoarthritis (OA) using a study conducted on Wistar rats. The rats were induced with OA through a combination of surgical methods known as ACLT (anterior cruciate ligament transection) along with medial meniscectomy. This allowed us to closely observe the direct impact of VITD on pain levels and cartilage health.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Read More
8
Vitamin D3 improves post-surgery pain
Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.
Highly relevant to knee surgery
We investigated the role of vitamin D3 in managing post-operative knee pain in patients undergoing unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups. One group received vitamin D3 supplements before surgery, another group received them afterward, and the last group had normal vitamin D levels from the start.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
Read More
8
Vitamin D's impact on KOA pain
The association of vitamin D with knee osteoarthritis pain: an analysis from the Osteoarthritis Initiative database.
Relevant but limited generalizability
We explored how Vitamin D affects knee pain in those suffering from knee osteoarthritis (KOA), a prevalent condition that significantly impacts the elderly. Using data from the Osteoarthritis Initiative, our analysis included 524 participants and focused on the relationship between serum Vitamin D levels and pain scores measured by the WOMAC scale.
Our findings indicated that higher levels of Vitamin D were linked to lower pain scores in men. This suggests that Vitamin D may be beneficial for male KOA patients. However, for women, we didn’t find any significant connection between Vitamin D levels and their pain scores.
We noticed a nonlinear relationship overall, which became less significant when we adjusted for other variables. This points to the possibility that Vitamin D could serve as a targeted treatment strategy for reducing knee pain in men, though it seems less effective for women. These exciting results highlight the need for further studies to verify if Vitamin D supplementation can indeed help alleviate KOA pain in male patients.
Our findings indicated that higher levels of Vitamin D were linked to lower pain scores in men. This suggests that Vitamin D may be beneficial for male KOA patients. However, for women, we didn’t find any significant connection between Vitamin D levels and their pain scores.
We noticed a nonlinear relationship overall, which became less significant when we adjusted for other variables. This points to the possibility that Vitamin D could serve as a targeted treatment strategy for reducing knee pain in men, though it seems less effective for women. These exciting results highlight the need for further studies to verify if Vitamin D supplementation can indeed help alleviate KOA pain in male patients.
Read More
8
Vitamin D aids knee pain relief
Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis.
Study assesses vitamin D effects
We explored how vitamin D supplementation impacts knee pain and other related factors in patients with knee osteoarthritis (KOA). A group of 165 KOA patients received 40,000 IU of vitamin D weekly for six months, and their treatment was compared against 25 healthy individuals.
Our findings revealed that patients with KOA had notably higher levels of an autophagosome protein, LC3A, compared to the healthy controls. After vitamin D supplementation, there was a significant reduction in serum LC3A levels, pointing toward an improvement in the autophagy process. This decrease in LC3A levels was also linked with a reduction in pain and better functional scores.
Additionally, we saw improvements in muscle strength and overall physical performance among those who received vitamin D. In essence, vitamin D not only helped lower inflammatory markers but also contributed to alleviating knee pain and enhancing mobility for KOA patients.
Overall, the evidence suggests that vitamin D can be an effective ally in managing knee pain and improving physical performance in individuals suffering from KOA.
Our findings revealed that patients with KOA had notably higher levels of an autophagosome protein, LC3A, compared to the healthy controls. After vitamin D supplementation, there was a significant reduction in serum LC3A levels, pointing toward an improvement in the autophagy process. This decrease in LC3A levels was also linked with a reduction in pain and better functional scores.
Additionally, we saw improvements in muscle strength and overall physical performance among those who received vitamin D. In essence, vitamin D not only helped lower inflammatory markers but also contributed to alleviating knee pain and enhancing mobility for KOA patients.
Overall, the evidence suggests that vitamin D can be an effective ally in managing knee pain and improving physical performance in individuals suffering from KOA.
Read More
8
Vitamin D improves knee discomfort
Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.
Direct impact on knee pain
We explored the relationship between 25-hydroxy vitamin D levels and knee osteoarthritis (KOA) by conducting a thorough analysis of eight randomized controlled trials (RCTs). This involved looking at nearly 3,100 patients and examining factors such as tibial cartilage volume, joint space width, synovial fluid volume, and patients' self-reported pain and function scores.
Our findings showed that vitamin D supplementation significantly improved certain aspects of knee health. Specifically, we observed notable reductions in pain levels and improvements in joint function, as measured by the WOMAC scale. Interestingly, while vitamin D helped with the overall discomfort and functionality of those suffering from knee issues, it did not significantly affect stiffness or some other knee-related measurements, like changes in joint space.
Given these results, it seems clear that for patients struggling with knee pain and dysfunction, vitamin D could be a valuable addition to their treatment regimen. However, it’s also worth noting that the most pronounced benefits appeared with dosages exceeding 2,000 IU daily, suggesting that dosage plays an important role in effectiveness.
Our findings showed that vitamin D supplementation significantly improved certain aspects of knee health. Specifically, we observed notable reductions in pain levels and improvements in joint function, as measured by the WOMAC scale. Interestingly, while vitamin D helped with the overall discomfort and functionality of those suffering from knee issues, it did not significantly affect stiffness or some other knee-related measurements, like changes in joint space.
Given these results, it seems clear that for patients struggling with knee pain and dysfunction, vitamin D could be a valuable addition to their treatment regimen. However, it’s also worth noting that the most pronounced benefits appeared with dosages exceeding 2,000 IU daily, suggesting that dosage plays an important role in effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Immense help
I’m very pleased with the quality and effectiveness of this D3, as it has greatly aided me concerning bone and joint strength, reduced knee pain, and appears to be easily absorbed. I will continue to purchase.
8.8
Less pain
Good in composition and acceptable in dosage for an adult. I drink one piece a day and have experienced less knee pain.
Frequently Asked Questions
No FAQs are available for this product and symptom.
